Novel Multi-System Functional Gains via Task Specific Training in Spinal Cord Injured Male Rats
نویسندگان
چکیده
منابع مشابه
Spinal Cord-Injured Rats
Opérant conditioning of the spinal stretch reflex or its electrical analog, the H-reflex, is a new model for exploring the mechanisms of long-term supraspinal control over spinal cord function. Primates and rats can gradually increase (HRup conditioning mode) or decrease (HRdown conditioning mode) the H-reflex when reward is based on H-reflex amplitude. An earlier study indicated that HRdown co...
متن کاملTime-related effects of general functional training in spinal cord-injured rats
OBJECTIVES This prospective, randomized, experimental study with rats aimed to investigate the influence of general treatment strategies on the motor recovery of Wistar rats with moderate contusive spinal cord injury. METHODS A total of 51 Wistar rats were randomized into five groups: control, maze, ramp, runway, and sham (laminectomy only). The rats underwent spinal cord injury at the T9-T10...
متن کاملFunctional recovery assessment of spinal cord contusion model in male rats without therapeutic interventions
Introduction: Spinal cord injury (SCI) is one of the most serious clinical diseases, which not only affects the patient's physical and mental status, but its effects will be spread to family and community. After severe spinal cord injury, astrocytes of the central nervous system (CNS) become reactive astrocytes, and play the main role of glial scar formation. The scar is a major obstacle to r...
متن کاملReaching training in rats with spinal cord injury promotes plasticity and task specific recovery.
In the current study we examined the effects of training in adult rats with a cervical spinal cord injury (SCI). One group of rats received 6 weeks of training in a single pellet reaching task immediately after injury, while a second group did not receive training. Following this period changes in cortical levels of BDNF and GAP-43 were analysed in trained and untrained animals and in a group w...
متن کاملEfficient testing of motor function in spinal cord injured rats.
In experimental spinal cord injury studies, animal models are widely used to examine anatomical and functional changes after different treatments and lesion types. A variety of behavioral paradigms exists in the literature, but definitions and criteria for motor performance vary considerably. In this study, we examined the outcome and relation of tests such as the BBB open field locomotion scor...
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ژورنال
عنوان ژورنال: Journal of Neurotrauma
سال: 2014
ISSN: 0897-7151,1557-9042
DOI: 10.1089/neu.2013.3082